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No6(2) 2019

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DOI 10.37219/2528-8253-2019-6-64
Minin YuV, Klys YuG, Burlaka YuB, Voroshylova NM, Kucherenko TI, Savchenko TD, Verevka SV
Indices of proteins’ and lipids’ peroxidation and the state of antioxidant system in patients with snoring
Minin Yuriy V.
State Institution “Institute of otolaryngology named after Prof. O.S. Kolomiychenko of the National Academy of Medical Sciences of Ukraine”; Kyiv, Ukraine
Department of inflammatory diseases of ENT-organs
Leading researcher
Doctor of Medical Sciences, Professor
E-mail: amtc@kndio.kiev.ua

Klys Julia G
State Institution “Institute of otolaryngology named after Prof. O.S. Kolomiychenko of the National Academy of Medical Sciences of Ukraine”; Kyiv, Ukraine.
Biochemistry laboratory
Researcher
PhD
E-mail: amtc@kndio.kiev.ua

Burlaka Julia B.
State Institution “Institute of otolaryngology named after Prof. O.S. Kolomiychenko of the National Academy of Medical Sciences of Ukraine”; Kyiv, Ukraine.
Laboratory of biochemistry
Researcher
PhD
E-mail: burlakaiuliia@yahoo.com
Orcid ID: http://orcid.org/0000-0003-0821-4268

Voroshilova Natalya M
State Institution “Institute of otolaryngology named after Prof. O.S. Kolomiychenko of the National Academy of Medical Sciences of Ukraine”; Kyiv, Ukraine.
Laboratory of biochemistry
Senior Researcher
PhD
E-mail: amtc@kndio.kiev.ua

Kucherenko Tetiana I.
State Institution “Institute of otolaryngology named after Prof. O.S. Kolomiychenko of the National Academy of Medical Sciences of Ukraine”; Kyiv, Ukraine.
Department of inflammatory diseases of ENT-organs, Senior Researcher
E-mail: tkucherenko@hotmail.com

Savchenko Tamila D.
State Institution “Institute of otolaryngology named after Prof. O.S. Kolomiychenko of the National Academy of Medical Sciences of Ukraine”; Kyiv, Ukraine
Department of Inflammatory Diseases of ENT Organs
Senior Researcher
E-mail: tamilads@ukr.net
ORCID ID: https://orcid.org/0000-0001-5550-5530

Verevka Sergiy V.
State Institution “Institute of otolaryngology named after Prof. O.S. Kolomiychenko of the National Academy of Medical Sciences of Ukraine”; Kyiv, Ukraine.
Laboratory of biochemistry, manager.
Doctor of Biological Sciences, Professor.
Email: verevka.biochem@gmail.com
ORCID ID: http://orcid.org/0000-0002-3578-7996

Abstract

Aim: to investigate the intensity of proteins and lipids peroxidation, the state of the antioxidant system and biochemical indices of endogenous intoxication in patients with snoring.
Materials and Methods: Blood serum of 20 patients with snoring and 19 healthy persons without any manifestation of respiratory complications at sleeping were studied. All patients were divided into two groups. Group I included 10 patients with moderate manifestation of snoring, and group II with the hard one.
Results: An increase of the proteins’ oxidative modifications in patients with snoring without obstructive apnea at sleep were moderate and severe, that is reflected by an increase of the levels of neutral- and basiccharacter aldehyde-dinitrophenyl-hydrazones and basic-character ketone-dinitrophenyl-hydrazones has been established. The level of thiobarbiturate-positive products in patients with the moderate degree of snoring was in the value of control group. At progression of this pathology this index increased, too in compare to control group. The level of catalase activity in patients of both group was increased where as the content of free thiol groups was decreased. The content of medium weight molecules in patients of both groups was on the level of control, but at progressing of the disease it increased. The content of tyrosine-containing peptides was increased in the serum of patients in both groups. Our data prove for the intensification of the proteins’ and lipids’ peroxidation, for the changes in antioxidant system and for the development of endogenous intoxication in patients with severe level of snoring.

Keywords

snoring, proteins’ and lipids’ peroxidation, antioxidant system, endogenous intoxication.


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